. 2016 May 16;6:25952. doi: 10.1038/srep25952

Table 2. Summary of twelve SNPs and response to chemotherapy and overall survival.

ID No.^a	Gene	location	Alleles	CR (%)	MAF	HWP	P for response^b			P for overall survival^c
ID No.^a	Gene	location	Alleles	CR (%)	MAF	HWP	dominant	recessive	additive	dominant	recessive	additive
rs2297136	PD-L1	3′UTR	TC	99.2	0.16	0.35	0.01	0.20	0.01	0.02	0.15	0.01
rs4143815	PD-L1	3′UTR	CG	96.6	0.40	0.67	0.21	0.01	0.02	0.47	0.18	0.23
rs822336	PD-L1	promoter	GC	99.5	0.26	0.73	0.67	0.11	0.31	0.68	0.95	0.72
rs822337	PD-L1	promoter	TA	96.6	0.34	0.88	0.75	0.16	0.36	0.30	0.27	0.19
rs822338	PD-L1	intron	CT	98.9	0.44	0.60	0.87	0.35	0.67	0.56	0.34	0.35
rs36084323	PD1	promoter	GA	97.6	0.47	0.31	0.13	0.19	0.08	0.99	0.42	0.62
rs2227982	PD1	missence	CT	98.9	0.46	0.15	0.20	0.09	0.07	0.96	0.53	0.74
rs10204525	PD1	3′UTR	AG	99.2	0.25	0.38	0.33	0.09	0.15	0.76	0.60	0.66
rs231775	CTLA-4	missence	GA	99.2	0.28	0.52	0.97	0.26	0.61	0.71	0.93	0.80
rs5742909	CTLA-4	promoter	CT	97.9	0.12	0.26	0.41	0.58	0.58	0.98	0.11	0.74
rs733618	CTLA-4	promoter	AG	98.7	0.45	0.91	0.37	0.80	0.47	0.46	0.70	0.48
rs11571316	CTLA-4	promoter	CT	98.2	0.16	0.56	0.91	0.34	0.86	0.89	0.95	0.91

Abbreviation: CR, call rate; MAF, minor allele frequency; and HWE, Hardy-Weinberg equilibrium.

^aInformation about SNPs and SNP ID were obtained from NCBI database (http://ncbi.nih.gov).

^bP values were calculated by multivariate regression analysis, adjusted for age, gender, smoking status, tumor histology, stage, ECOG performance status, and weight loss.

^cP-values were calculated using multivariate Cox proportional hazard models, adjusted for age, gender, smoking status, tumor histology, stage, ECOG performance status, weight loss, 2nd line chemotherapy and radiation to primary tumor.