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. 2016 May 16;6:26097. doi: 10.1038/srep26097

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Levels of Immune mediators (Pro-inflammatory cytokines, anti-inflammatory cytokines, chemokines and growth and other factors) during acute CHIKV infection (samples collected during the admission stage of hospitalization) from two groups of patients (86 children and 64 adults) were analyzed and presented in heat map of normalized scores. In the heat map presentation, the immune mediator concentrations were scaled between 0 and 1 for each measured immune mediator and then the average scaled value computed for each group. Blue colors represent the lowest average scaled value while pink colors represent the highest average scaled value. Immune mediators levels of healthy adults (n = 8) were included as reference point. Differences between the two groups were analyzed using Mann-Whitney U-test, with Bonferroni correction.