Figure 2. Differentially-regulated immune mediators profiles in children.

Levels of immune mediators during acute CHIKV infection (samples collected during the admission stage of hospitalization) were analyzed. Patients were grouped into early viral clearance (n = 30), and prolonged viremia (n = 34) groups and compared and presented in heat map of normalized scores. In the heat map presentation, the immune mediator concentrations were scaled between 0 and 1 for each measured immune mediator and then the average scaled value computed for each group. Blue colors represent the lowest average scaled value while pink colors represent the highest average scaled value. Differences between the two groups were analyzed using Mann-Whitney U-test, with Bonferroni correction.