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. 2016 May 16;6:25796. doi: 10.1038/srep25796

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A structural overlay of (A) SEA and SEE, (B) SEB and SEC3, (C) SEH, (D) SEA, SEB, SEC3, SEE and SEH. Hot-spot residues for which alanine substitutions have destabilizing effects on ΔΔG_complex of more than, or equal to 1 kcal/mol, are shown as sticks. (E) Sequence alignment of the five superantigens (SEA, SEB, SEC3, SEE and SEH).