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. 2016 Apr 14;37(6):1511–1520. doi: 10.3892/ijmm.2016.2565

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(A and B) Evolutionary conservation analyses of the MYH7, p.Asn885Thr and TNNT2, p.Arg296His mutations were performed, respectively. Clustal W was used to align sequences from Homo sapiens, Macaca mulatta, Felis catus, Mus musculus, Gallus gallus, Danio rerio and Xenopus tropicalis and WebLogo was used to generate sequence logos. The MYH7, p.Asn885Thr and TNNT2, p.Arg296His mutations are marked by a black arrow; (C and D) Results of the PolyPhen-2 analysis predicting the pathogenicity of the mutations of MYH7, p.Asn885Thr and TNNT2, p.Arg296His, respectively.