TABLE 3.
Summary of Qualitative Analysis of 122 Musculoskeletal Tumors Analyzed With Proton MR Spectroscopy
| No. of Cases |
||
|---|---|---|
| Lesion | Total | Discrete Choline Peak Present |
| Benign | ||
| Abscess | 1 | 1 |
| Baker cyst | 1 | 0 |
| Bone cyst | 3 | 0 |
| Bursitis | 1 | 0 |
| Desmoid | 2 | 0 |
| Elastofbroma | 1 | 0 |
| Enchondroma | 2 | 2 |
| Fibrous dysplasia | 2 | 1 |
| Ganglion | 2 | 0 |
| Giant cell tumor | 16 | 6 |
| Giant cell tumor of tendon sheath | 1 | 0 |
| Granuloma | 1 | 0 |
| Hemangioma | 3 | 0 |
| Hematoma | 3 | 0 |
| Heterotopic ossifcation | 1 | 0 |
| Lipoma | 5 | 0 |
| Lipogranuloma | 1 | 0 |
| Nodular fasciitis | 1 | 0 |
| Pilomatricoma | 1 | 0 |
| Benign peripheral nerve sheath tumor | 9 | 9 |
| Stress reaction | 1 | 0 |
| Trichilemmal cyst | 1 | 0 |
| Tuberculous arthritis | 1 | 0 |
| Unknowna | 2 | 1 |
| Total | 62 | 20 |
| Malignant | ||
| Chondrosarcoma | 4 | 3 |
| Epithelioid sarcoma | 1 | 1 |
| Ewing sarcoma | 4 | 4 |
| Fibrosarcoma | 1 | 1 |
| Fibromyxoid sarcoma | 1 | 0 |
| Hemangiopericytoma | 1 | 0 |
| Leiomyosarcoma | 2 | 2 |
| Liposarcoma | 4 | 2 |
| Lymphoma | 2 | 2 |
| Malignant fbrous histiocytomab | 3 | 3 |
| Metastasis | 18 | 18 |
| Malignant peripheral nerve sheath tumor | 3 | 3 |
| Myofbroblastic sarcoma | 1 | 1 |
| Osteosarcoma | 14 | 12 |
| Synovial sarcoma | 1 | 1 |
| Total | 60 | 53 |
Note—Seven cases have not been reported in the literature. Otherwise, only peer-reviewed studies that included a detailed list of tumor types and corresponding choline signal analysis were included [4, 5, 8, 10–12]. Imaging was performed at 1.5 and 3 T, with both single-voxel and multivoxel spectroscopic techniques, and varied in method of choline content analysis (qualitative analysis, relative quantification, or absolute quantification). The results of the studies in which quantitative results were reported were reclassified as categoric data (qualitative data reported as presence or absence of choline peak) to facilitate overall comparison.
Two lesions reported as unknown but thought to be benign on basis of clinical and radiographic findings [5].
For brevity the term malignant fibrous histiocytoma is used. This term has been changed to high-grade undifferentiated pleomorphic sarcoma in the World Health Organization classification.