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. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Arch Biochem Biophys. 2016 Mar 29;597:30–47. doi: 10.1016/j.abb.2016.03.030

Table 1. Responses of liver P450 Cytochrome genes to Cyp1b1 deletion and diet changes.

	LFD-KO^a	HFD^a	HFD-KO^b
Gene	(KO/WT)	(HFD/LFD)	(KO/WT)
Cyp1a2	2.5^*	2.1	2.2
Cyp2a4	-5.0^**	2.2^*	-2.7^**
Cyp2a5	-4.5^**	2.3^**	-3.0^**
Cyp2b13	-6.6^*	3.5	-30.3^**
Cyp2b10	-1.5	4.2	-12.4^*
Cyp2b9	-7.4^*	4.1	-41.1^**
Cyp2c29	1.6	2.2^*	n.c.
Cyp2c37	2.0	4.4^*	n.c.
Cyp2c39	n.c.	3.0^*	n.c.
Cyp2c40	2.1^*	1.5	n.c.
Cyp2c54	3.5	7.4^**	n.c.
Cyp2c55	-2.1^*	-1.5	-1.6
Cyp2c70	3.0^**	n.c.	2.8^**
Cyp2e1	2.6	3.9^*	n.c.
Cyp3a11	-2.2^*	n.c.	-2.1
Cyp3a16	-4.0^**	-1.8	-2.6^*
Cyp3a41a	-4.0^**	-1.7	-2.4^*
Cyp3a44	-3.4^**	-1.8	-2.1
Cyp4a10	-11.7^**	1.7	-11.2^**
Cyp4a12	2.5	n.c.	1.7
Cyp4a14	-43.4^**	n.c.	-66.3^**
Cyp4a31	-5.1^**	2.0	-6.4^**
Cyp4v3	2.2^*	1.7	2.0^*
Cyp7a1	-2.6	2.3	-1.8
Cyp7b1	11.4^**	3.4	-4.6^*
Cyp8b1	1.5	2.1	n.c.
Cyp17a1	-3.5^**	-1.9	-2.5^*
Cyp39a1	-5.7^**	n.c.	-9.3^**

Data represents fold change.

Male (n=3) mice were fed the diets for 11 weeks post-weaning.

^a

Expression levels are calculated relative to WT LFD.

^b

Expression levels are calculated relative to WT HFD.

n.c. represents no change (FC<±1.5).

^*

p<0.05,

^**

p<0.01