. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Arch Biochem Biophys. 2016 Mar 29;597:30–47. doi: 10.1016/j.abb.2016.03.030

Table 2. Expression of liver genes involved in metabolism divided according to responses to Cyp1b1-ko and diet responses.

	LFD-KO^a	HFD^a	HFD-KO^b
	(KO/WT)	(HFD/LFD)	(KO/WT)
Group A
Acot1	-4.4^**	1.5	-4.7^**
Acot4	-2.7^**	1.5	-3.7^**
Akr1c19	-3.0^**	n.c.	-2.7^**
Cd36	-7.6^**	-1.7	-2.5^**
Cidec	-4.7	-1.9	-4.8
Cyp4a10	-11.7^**	1.7	-11.2^**
Cyp7b1	13.0^**	4.0	5.0^*
Egfr	2.4^**	n.c.	2.6^*
Enho/Adropin	2.2	2.0	3.9
Fgf21	-3.1^*	-2.9^*	-2.9^*
G0s2	-2.5^*	n.c.	-2.6^*
Gsta2	-5.6^**	-1.8	-2.8^*
Gstp1	2.1^**	n.c.	3.1^**
Hamp2	-2.2^*	-1.5	-5.5^**
Lgals1	-4.8^**	n.c.	-5.0^**
Lifr	4.2^**	2.3^*	3.5^**
Lpin2	-1.7	n.c.	-2.4^**
Nudt7	2.1^**	n.c.	3.1^**
Mgst3	-4.7^**	n.c.	-4.6^**
Nqo2	-2.0^*	n.c.	-1.8^*
Pex11a	-2.4^**	n.c.	-2.1^*
Plin4	-3.5^*	n.c.	-5.5^*
Pparg	-4.5^**	n.c.	-4.6^**
Ppp1r3c	3.8^*	1.6	2.4
Ppp1r3g	-4.6^*	-2.4	-5.9^**
Selenbp1	2.4^**	n.c.	2.5^**
Vldlr	-9.1^**	n.c.	-2.5^*
Vnn1	-10.0^**	2.3	-6.8^**
Group B
Elovl5	n.c.	-1.7	-2.2^*
Igfbp1	-1.7	-3.5	-5.1^*
Me1	n.c.	-1.7	-7.5^**
Osgin1	1.5	-1.5	2.7^*
Pdk4	-2.0	-3.1^*	-3.7^**
Scd1	n.c.	-3.9^*	-6.0^**
Socs2	1.5	-2.7	5.0^*
Group C
Ccl2	-3.5^*	-3.1^*	-1.8
Cd34	-2.5^*	-2.7^*	-1.5
Gas6	-2.2^**	-2.2^**	-1.6^**
Hes6	1.9^**	n.c.	2.1
Hsd3b5	15.3^*	6.6	2.3
Klf6	-2.9^**	-2.4^**	-1.5
Map4k4	-3.2^**	-2.8^**	-1.8
Mup3	4.7^*	3.4	1.5
Nupr1	-5.1^**	-5.5^**	n.c.
Slco1a1	5.2^*	4.2	1.7
Spp1	-2.6^*	-2.0	n.c.
Group D
Abcc3	-3.2^**	2.4	-5.5^**
Aldh1a1	-1.8^*	3.1^*	-1.7
Aldh3a2	-2.6^**	2.4^*	-2.4^**
Asns	1.8	-3.1^*	11.2^**
Cdh1	n.c.	-2.5^**	2.8^**
Cyp2a4	-5.0^**	2.2^*	-2.7^**
Cyp2b13	-6.6^*	3.5	-30.3^**
Cyp2b9	-7.4^*	4.0	-41.1^**
Hpgd	n.c.	2.5^**	-2.5^**
Ntrk2	1.6	-14.6^**	13.5^**
Rgs16	5.0	15.0^*	-16.0^*
Group HF
Acacb	n.c.	-3.2^*	-1.9
Cyp2c29	1.6	2.2^*	n.c.
Cyp2c37	n.c.	4.1^*	n.c.
Cyp2c39	n.c.	2.9^*	n.c.
Cyp2c54	3.48	7.41^**	n.c.
Gadd45g	n.c.	-3.9^**	-1.5
Icam1	n.c.	-3.6^*	1.8
Lpl	-1.5	-3.3^*	1.5
Nr0b2/Shp	n.c.	2.4^**	n.c.
Nr4a1/Nurr77	n.c.	-3.5^**	n.c.
Nr1i3/CAR	n.c.	3.0^*	-1.5
Rbp1	n.c.	-2.3^*	n.c.
Relb	-1.8	-3.0^**	n.c.
Scd2	-2.3	-4.5^*	n.c.
Slco1b2	1.5	2.5^*	n.c.
Sult1b1	n.c.	3.0^**	n.c.
Tubb2a	n.c.	-2.8^*	n.c.

Data represents fold change.

Male (n=3) mice were fed the diets for 11 weeks post-weaning.

Expression levels are calculated relative to WT LFD.

Expression levels are calculated relative to WT HFD.

n.c. represents no change (FC<±1.5).

p<0.05,

^**

p<0.01