Table 7. Female dw36 responses to HFD typically reversed by Cyp1b1-ko.
| LFD-KOa | WTa | HFD-KOb | |
|---|---|---|---|
| (KO/WT) | (HFD/LFD) | (KO/WT) | |
| OxS/ Inflammation | |||
| Krt 23 | n.c. | 9.1 | -5.0 |
| Gsta1 | -1.7 | 3.2 | -4.0 |
| Gpc1 | n.c. | 4.4 | -2.5 |
| Slc25a47 | 2.3 | 4.2 | -2.4 |
| Inhbe | 1.7 | 3.8 | -1.7 |
| Ephx1 | 1.3 | 3.1 | -2.3 |
| Saa1 | -2.4 | 2.6 | -2.2 |
| PPARα | |||
| Ppara | 2.2 | 3.2 | n.c. |
| Vnn1 | -1.4 | 2.9 | -2.8 |
| Angptl4 | 6.6 | 9.5 | -1.7 |
| Cyp4a10 | 1.9 | 5.4 | -1.5 |
| Acot1 | 3.6 | 5.1 | -1.7 |
| Aox1 | 1.6 | 2.7 | -1.8 |
| Cpt1a | 2.1 | 3.7 | -1.4 |
| FA-Oxidation | |||
| Fitm1 | n.c. | 7.9 | -4.2 |
| Hmgcs2 | 1.4 | 2.6 | -2.0 |
| Ech1 | n.c. | 2.6 | -1.6 |
| Lipid Synthesis | |||
| Pparγ | n.c. | 2.2 | -2.4 |
| Hes6 | -1.9 | -4.2 | 2.8 |
| Cholesterol | |||
| Aacs | -1.6 | -6.4 | 2.3 |
| Fdps | n.c. | -4.5 | 2.1 |
| Sqle | n.c. | 4.2 | 2.6 |
| Mvd | n.c. | -3.5 | 1.9 |
| Hmgcr | n.c. | -3.5 | 1.9 |
| Fatty Acid Synthesis | |||
| Elovl6 | -2.5 | -14.9 | n.c. |
| Acacb | n.c. | -4.6 | 1.7 |
| Fasn | -2.3 | -11.1 | n.c. |
| Scd1 | -1.4 | -4.1 | -2.3 |
| Pdk4 | -1.9 | -3.3 | -1.5 |
| Me1 | -2.3 | -6.2 | -1.6 |
| Fabp4 | -3.5 | -2.8 | 1.7 |
Data represents fold change.
Female (n=2) mice were fed the diets for 36 weeks post-weaning.
a
Expression levels are calculated relative to WT LFD.
b
Expression levels are calculated relative to WT HFD.
n.c. represents no change (FC<±1.5).