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. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Arch Biochem Biophys. 2016 Mar 29;597:30–47. doi: 10.1016/j.abb.2016.03.030

Table 8. Responses to HNF4α deletion compared to effects of Cyp1b1 deletion.

Gene Symbol	KO LFD^a	HNF4α-KO^[15]^b
Acot3	-10.7^**	8.9^**
C8b	2.9^**	-6.5^**
C9	2.3^**	-21.6^**
Cd36	-6.7^**	10.9^**
Cidec	-4.7	-1.3^**
Cyp17a1	-3.4^**	3.9^**
Cyp2a4	-5.0^**	2.8^**
Cyp2a5	-4.5^**	2.1^**
Cyp2b10	-1.5	1.9^**
Cyp2b13	-6.6^*	3.7^**
Cyp2b9	-7.4^*	8.5^**
Cyp2c40	1.3	-2.0^**
Cyp39a1	-5.7^**	2.9^**
Cyp4a14	-43.4^**	2.4^**
Cyp7a1	-2.6	-1.2^*
Cyp7b1	11.4^**	-23.7^**
Cyp8b1	1.5	11.3^**
Egfr	3.1	-9.3^**
Gdf15	-3.3^**	1.6^**
GhR	1.3	-5.0^**
Hamp2	-2.3^*	5.7^**
Hsd17b2	2.1^**	-2.7^**
Hsd3b2	1.8^*	-12.4^**
Hsd3b5	15.4^*	-11.1^**
Marco	-3.0	2.4^**
Mug2	1.8^*	-8.1^**
Mup1	7.5^**	-8.1^**
Mup3	1.8	37.6^**
Mup4	4.7^*	-12.7^**
Nudt7	2.4^**	-6.5^**
Prodh	2.2^*	-2.0^**
Rarres1	2.6^**	-17.1^**
Selenbp1	2.4^**	-3.7^**
Serpina7	-3.5^**	7.1^**
Spp1	-2.6^*	8.0^**
Vldlr	-9.1^**	10.7^**
Vnn1	-10.9^**	2.2^**

Data represents fold change.

Male (n=3) mice were fed the diets for 11 weeks post-weaning and compared to HNF4α- ko [15].

^a

Expression levels are calculated relative to WT LFD.

^b

Expression levels are calculated male liver-specific HNF4α-ko relative to male WT [15].

^*

p<0.05,

^**

p<0.01