. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Arch Biochem Biophys. 2016 Mar 29;597:30–47. doi: 10.1016/j.abb.2016.03.030

Table 9. Responses to SHP deletion compared to effects of Cyp1b1 deletion.

	SHP-KO	Cyp1b1-KO Male^a		Cyp1b1-KO Female^b
Gene Symbol	WD FC^[42]^e	LFD FC^c	HFD FC^d	LFD FC^c	HFD FC^d
Type A
Ccl4	-9.5^**	-5.5^**	-2.4^*	-2.2	1.0
Ubd	-8.5^*	-5.8^**	-5.0^**	-2	-1.1
Gsta2	-6.7^**	-5.6^**	-2.8^*	-1.2	-3.1
Serpina7	-4.4^**	-3.5^**	-9.4^**	-1.9	-1.6
Mgst3	-3.7^**	-4.7^**	-3.1^**	-1.5	-1.5
Cxcl10	-3.5^**	-3.8^*	-3.6^*	-2.4	-1.5
Pparg	-3.1^**	-4.5^**	-4.6^**	-1.3	-2.2
Lgals1	-2.9^**	-5.8^**	-5.2^**	-2.8	-3.9
Gdf15	-2.9^**	-3.3^**	-2.9^*	-4	-1.8
Fgf21	-2.4^**	-3.1^*	-2.9^*	-1.3	-1.8
Adora1	-1.7^*	-2.4^**	-2.5^**	1.1	-3.1
Cyp1a2	1.5^*	2.5^*	2.2	-1.4	1.5
Serpina11	1.8	2.3^**	2.8^**	1.9	2.2
Nudt7	2.0	2.4^**	2.4^**	-1.1	1.9
F11	2.3^**	2.2^**	2.0^**	2.9	2.2
C8b	2.9^**	2.9^**	2.7^**	1.4	1.9
Cyp7b1	5.1^**	11.4^**	4.6^*	3.2	2.8
Cidec	-11.6^**	-4.7	-4.8	-1.7	-1.3
Ms4a7	-6.7^**	-4.9^**	-2.4^*	-1.6	-1.4
Cd83	-3.9^*	-2.3^*	-2.3^*	1.0	-1.4
Cyp17a1	-3.0^*	-3.4^**	-2.5^*	-1.1	1.1
Osbpl3	-2.6^**	-14.1^**	-7.9^**	1.1	-1.3
Unc5b	-1.9	-3.6^**	-2.4^**	1.2	1.0
Akr1c19	-1.7	-3.1^**	-2.7^**	-1.0	1.2
Plxna2	-1.6	-2.3^**	-2.5^**	1.4	-1.2
Aadat	1.6	2.2^**	2.1^*	1.3	1.0
Selenbp2	3.3^*	3.4^**	2.2^**	-1.0	1.4
Type B
Tnfrsf19	-2.3^*	-1.5	-2.5^**	1.3	-1.5
Il1b	-1.7^*	-1.5	-1.7^*	1.0	-1.2
Hmgn2	2.3^**	1.4	2.2^**	1.9	1.7
C8a	1.5^*	1.8^**	2.2^**	1.6	1.4
Hapln4	1.9^**	1.4	2.6^**	-1.1	1.1
Type C
Ly6d	-15.7^**	-6.1^**	-1.6	-5.2	-2.4
Trem2	-12.4	-3.3^*	-1.2	-1.9	-1.3
Gal3st1	-12.1^**	-3.3^*	-2.1	1.5	-1.1
Atf3	-10.9^**	-2.9^*	-1.1	-1.8	1.0
Anxa2	-7.1^*	-2.9^*	-1.1	-1.5	-1.0
Nrg1	-5.8^**	-7.2^**	-1.4	1.7	-1.1
Serinc2	-5.2^**	-2.2^*	-1.2	1.3	-2.2
Nupr1	-5.0^**	-5.1^**	-1.3	-2.8	1.1
Cd52	-4.8^**	-2.7^**	-1.4	-2.8	-1.0
H2-Eb1	-3.8	-2.2^**	-1.7^*	-2.1	-1.1
Sprr1a	-3.4^**	-2.9^**	-1.3	1.7	-1.1
5430435G22Rik	-3.2	-2.3^**	-1.4	-1.9	1.2
Cd14	-3.2^**	-3.0^*	-1.3	-1.8	-1.4
Slamf9	-3.1^*	-2.5^**	-1.0	-1.6	-1.3
Gpx7	-2.7	-2.4^**	-1.3	1.7	1.2
Gas6	-2.5^**	-2.1^**	-1.7^**	-1.9	-1.1
Tmsb4x	-2.2^**	-2.3^**	-1.2	-1.9	1.2
Spp1	-2.2^**	-2.6^*	-1.2	-1.2	-1.7
Als2cr4/ Tmem237	-2.1^**	-2.1^**	-1.4	1.6	-1.2
Trib3	-1.9^*	-2.7^*	-1.7	1.8	-1.1
Csnk1e	-1.7^*	-2.5^**	-1.7	1.5	1.3
Fgf1	1.7^**	2.3^**	1.2	1.5	1.1
Slc17a3	1.8^**	2.7^**	1.8^**	1.1	1.4
Hes6	2.0	2.6^**	1.7	-1.9	2.8
Slc30a10	2.0	2.2^*	1.4	-1.5	-1.3
Scnn1a	2.3^**	2.1^**	1.2	1.4	1.5
Serpina3k	2.7^**	2.5^**	1.5^**	2.5	1.9
Avpr1a	3.8^**	2.3^*	1.5	-1.2	1.7
Hsd3b5	243.3^**	15.4^*	2.3	5.2	1.3
Sdcbp2	-61.5^**	-4.5^*	-1.2	1.7	1.0
Cd63	-5.7^**	-3.1^*	-1.4	-1.4	1.1
Uap1l1	-5.7^**	-3.5^*	1.2	-1.1	1.0
Spats2l	-3.7^**	-2.1^*	-1.4	1.1	-1.0
Slc41a3	-3.5^**	-2.1^*	-1.0	1.2	1.1
Anxa5	-3.2^**	-2.4^*	-1.3	-1.3	-1.3
Tmsb10	-3.2	-2.9^*	-1.2	-1.2	1.2
Cpxm1	-3.1^*	-3.0^**	-2.0	-1.1	1.2
Iqgap1	-2.8^**	-2.2^*	-1.0	-1.3	-1.2
Rhoc	-2.3	-2.8^**	-1.1	1.2	1.2
Serpina3g	-2.2	-2.1^*	-1.4	-1.2	-1.4
Ddit3	-2.1^**	-2.6^*	-1.7	-1.1	-1.2
Cxadr	-2.1^**	-3.0^**	-1.6	-1.4	-1.2
Cdc42ep5	-2.1^**	-2.9^**	-1.3	1.4	-1.1
Renbp	-2.0^**	-3.2^**	1.2	1.3	1.1
Ank3	-1.7	-3.5^**	-1.9^**	1.2	-1.2
AI317395	1.5^**	2.7^**	1.6	-1.0	-1.0
Gulo	1.6^**	2.1^*	1.6	1.3	1.3
Bach2	1.6^**	3.0^**	2.0^*	1.2	-1.0
Hsd3b2	1.6	2.2^**	1.2	1.2	-1.0
Rnase4	1.8	2.1^**	1.4^*	1.0	1.2
Npr2	2.1^**	2.2^*	1.5	1.1	-1.2
Mup4	5.9	4.7^*	2.0	-1.0	1.3

Data represents fold change.

Male (n=3) mice were fed the diets for 11 weeks post-weaning and compared to HNF4α-ko [15], *p<0.05, **p<0.01.

Female (n=2) mice were fed the diets for 36 weeks post-weaning and compared to HNF4α-ko [15].

Expression levels are calculated relative to WT LFD

Expression levels are calculated male liver-specific HNF4α-ko relative to male WT [15],

p<0.05,

^**

p<0.01.