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. 2016 May 10;57(6):2584–2592. doi: 10.1167/iovs.15-19006

Figure 3.

Figure 3

Effect of Ex-4 on TNF and/or VEGF-induced retinal endothelial cells permeability. We grew BREC to confluence on transwell filters and the monolayer permeability to RITC-70 kDa dextran was measured over the following 4 hours after the several treatments. Exendin-4 does not block TNF and/or VEGF-induced permeability in cultured BREC. We treated BREC with 10 nmol/L Ex-4 1 hour before TNF (5 ng/mL, 1.5 hours) and/or VEGF (50 ng/mL, 30 minutes) treatment. Average rate of Po for the control was 5.5 × 10−7 cm/s. The results represent the mean ± SEM (n ≥ 3). *P < 0.05, ***P < 0.001 versus control. One-way ANOVA followed by Bonferroni's post hoc test.