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. 2016 May 16;14:134. doi: 10.1186/s12967-016-0895-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Biodistribution of vector DNA. Quantitative PCR values for mean copies per reaction and mean copies per μg of DNA for systemic organs and tissues at day 6 after vector administration. Tissues listed are those positive for viral DNA in each animal. Animals are delineated by group number and gender. The analyzed measurements are shown as mean copies per sample in the log₁₀ scale. Each plot represents the average of duplicate samples and standard deviations are indicated by error bars. One-way ANOVA and Kruskal–Wallis test were used for comparison between viral copies in different organs/blood and those present at the injection site. *P < 0.05. G4 Vector mid 2.5 × 10⁸ vp/animal, G5 vector high 2.5 × 10⁹ vp/animal, IS injection site, BM bone marrow