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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Crit Care Med. 2015 Aug;43(8):1612–1621. doi: 10.1097/CCM.0000000000001022

TABLE 2.

Medications, Off-Label Use, and Adverse Drug Reaction: By Site

Description Total Site 1 Site 2 Site 3
No. of medications evaluated 16,391 8,821 4,386 3,184

Patient days 1,654 931 367 356

Medications off-label 7,056 3,846 1,791 1,419
  Nonindicated population 159 0 4 14
  Nonindicated use 5,756 3,182 1,540 1,119
  Nonindicated dose 895 544 187 220
  Nonindicated route 246 120 60 66

Total ADRs 126 49 58 19

ADRs with one drug culprit 116 47 50 19
  Off-label 51 16 24 18
  Off-label due to indication 45 12 17 16

ADR = adverse drug reaction.