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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Kidney Int. 2016 Jan;89(1):12–14. doi: 10.1016/j.kint.2015.10.007

Figure 1. The Src kinase promotes fibroblast activation and kidney fibrosis by integrating multiple fibrogenic signal inputs.

Figure 1

Upon stimulation by various extracellular cues such as transforming growth factor-β1 (TGF-β1), angiotensin II (Ang II), epidermal growth factor (EGF), or extracellular matrix (ECM), intracellular Src kinase is activated. Src activation leads to phosphorylation of the signaling proteins STAT3, AKT, and plasma membrane epidermal growth factor receptor (EGFR). Activation of Src also promotes TGF-β1–mediated Smad3 activation by multiple mechanisms (dashed line).