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. 2016 May 5;1(6):e86660. doi: 10.1172/jci.insight.86660

Figure 2. Th17-prone CD4+CD146+CCR5+ T cell population.

Figure 2

(A) Differential transcriptomes in CD146+CCR5+ Tcons versus Tcons excluding this population. (B) RORC and IL-17 expression in patients’ samples (n = 35 and 41, respectively). (C) Th1 or Th17 differentiation of naive T cells with anti-CD3/CD28 stimulation. Representative plots showing CD146 expression in CD4+ T cells and a dot plot depicting mean ± SEM values for frequency of CD146 (n = 16), 2-tailed Student’s t test. (D) Th1 or Th17 differentiation of naive T cells with anti-CD3/CD28 or anti-CD3/ICOS stimulation. Representative plots of CD146 and CCR5 expression and a dot plot depicting mean ± SEM values for frequency of CD4+CD146+CCR5+ T cells (n = 4), 2-tailed Student’s t test. (E) Representative plots showing IL-17 and IFN-γ coexpression in CD4+ T cells and a dot plot depicting mean ± SEM values for frequency of IL-17+IFN-γ+ T cells in the same 4 conditions as in E (n = 7), 2-tailed Student’s t test.