Fig 1. The importance of acetylation of STAT3 (pdb:1BG1) and lysine acetylation equation.

(A) Jak-STAT signaling pathway, including phosphorylation and acetylation. (B) The schematic diagram of HSE. An acetyl group (CH₃CO-) from Ace-CoA replaces the hydrogen atom in the epsilon-amino group (-NH₃⁺)(blue) of side chain (red) of lysine residue, and the side chain of Lys685 is located at the upper half sphere which contains C_β atom. (C) DNA binds to STAT3 homo-dimer, and surface of STAT3 is colored by CHOPS[5] score, a convex measure of protein surface. (D) Lysine acetylation equation.