Fig 2. Body weight of mice before and during the development of obesity.

Body weight of mice was monitored at the 2-week intervals starting at 2 weeks of age and continuing until the end of experiment (week 24). All mice were fed a standard laboratory chow (STD) until the age of 12 weeks, when most of the mice received a high-fat diet (HFD); the remaining mice continued on the STD diet until the end of study. Both male (A) and female (B) mice were followed during the experiment. The data are means ± SD (STD, empty circles, n = 14 (male) or 11 (female); HFD, black circles, n = 82 (male) or 73 (female)).