Skip to main content
. 2016 May 16;11(5):e0155261. doi: 10.1371/journal.pone.0155261

Fig 3. Antiviral activity of TNC in low pH conditions and in the presence of other mucosal innate HIV-1 inhibitors.

Fig 3

(A) Neutralization potency of purified TNC was measured after low pH treatment to simulate the low pH of the vaginal compartment against HIV-1 C.DU156. (B) Neutralization potency of purified TNC starting at 200 μg/ml, purified lactoferrin starting at 500 μg/ml, and TNC plus lactoferrin (reported in TNC concentration) was determined against HIV-1 C.DU156 in TZM-bl cells. (C) In a separate assay, purified TNC starting at 200 μg/ml, recombinant MUC-1 starting at 200 μg/ml, and TNC plus MUC-1 (reported in TNC concentration) was determined against HIV-1 C.DU156. Neither the addition of purified lactoferrin or MUC-1 to TNC had additive or inhibitory effects on TNC’s HIV-1 neutralizing potency.