Table 1. Characteristics, predisposing factors and severity of illness in 430 patients with Staphylococcus aureus bacteremia (SAB) stratified according to 30-day mortality.
OR = odds ratio for fatal outcome. HR = hazard ratio for fatal outcome, 95% CI = 95% confidence interval. All values are given as number of patients (%).
| Univariate analysis | Multivariate analysisf | |||||
|---|---|---|---|---|---|---|
| Fatalitiesn = 53 (12) | Survivors n = 377 (88) | OR (95% CI) | p- value | HR (95% CI) | p-value | |
| Age >60 years | 43 (80) | 174 (46) | 5.0 (2.4–10.3) | <0.0001 | 4.2 (2.0–8.6) | <0.0001 |
| Male sex | 33 (62) | 235 (62) | 1.0 (0.6–1.8) | 1.000 | - | - |
| Healthcare-associated SAB | 32 (60) | 200 (53) | 1.3 (0.8–2.4) | 0.378 | - | - |
| Foreign bodyb | 12 (23) | 100 (27) | 0.8 (0.4–1.6) | 0.619 | - | - |
| Intravenous drug abusea | 1 (2) | 43 (11) | 0.15 (0.0–1.1) | 0.029 | - | - |
| Immunosuppressive treatment | 16 (30) | 42 (11) | 3.5 (1.8–6.7) | <0.0001 | 1.8 (0.9–3.3) | 0.087 |
| Chronic alcoholism | 11 (21) | 37 (10) | 2.4 (1.1–5.1) | 0.032 | 2.7 (1.2–6.1) | 0.017 |
| Diabetes | 13 (25) | 95 (25) | 1.0 (0.5–1.9) | 1.000 | 0.5 (0.3–1.19 | 0.090 |
| Chronic renal failurec | 14 (26) | 46 (12) | 2.6 (1.3–5.1) | 0.010 | 2.3 (1.1–5.1) | 0.037 |
| Liver disease | 7 (13) | 60(16) | 0.8 (0.3–1.9) | 0.691 | - | - |
| Malignancy | 13 (25) | 50 (13) | 2.1 (1.0–4.3) | 0.038 | - | - |
| HIV | 1 (2) | 7 (2) | 1.0 (0.1–8.2) | 1.000 | - | - |
| Ultimately or rapidly fatal diseased | 31 (59) | 88 (23) | 4.6 (2.5–8.4) | <0.0001 | 2.1 (1.1–4.0) | 0.033 |
| Severe sepsise | 12 (23) | 25 (7) | 4.1 (1.9–8.8) | 0.001 | 2.1 (1.0–4.3) | 0.054 |
| Any deep infection | 51 (96) | 300 (80) | 6.5 (1.6–27.5) | 0.002 | 4.1 (0.9–18.4) | 0.065 |
| Deep seated abscess | 23 (43) | 162 (43) | 1.0 (0.6–1.8) | 1.000 | - | - |
| Osteomyelitis | 17 (32) | 124 (33) | 1.0 (0.5–1.6) | 1.000 | - | - |
| Pneumonia | 34 (64) | 118 (31) | 3.9 (2.2–7.2) | <0.0001 | 2.0 (1.1–3.7) | 0.033 |
| Foreign body infection | 9 (17) | 70 (19) | 0.9 (0.4–1.9) | 1.000 | - | - |
| Endocarditis | 17 (32) | 57 (15) | 2.6 (1.4–4.9) | 0.006 | 2.5 (1.4–4.7) | 0.004 |
| Septic arthritis | 4 (8) | 52 (14) | 0.5 (0.2–1.5) | 0.276 | - | - |
aInjection drug use within 6 months.
bForeign body implanted within a year.
cConstantly elevated serum creatinine (≥180 μmol/l).
dAccording to the criteria of McCabe and Jackson [22].
eSevere sepsis during the 3 days from the blood culture time point.
f Cox regression analysis -2 log likelihood was 547.718 and model chi-square 100.102, p<0.0001