Table 2. Cut-off values for C-reactive protein (CRP) levels (mg/L) and white blood cell counts (WBC) in finding patients with fatal outcome among 430 patients with Staphylococcus aureus bacteremia.
OR = odds ratio for fatal outcome. HR = hazard ratio for fatal outcome, 95% CI = 95% confidence interval. All values are given as number of patients (%).
| Univariate analysis | Multivariate analysisa | |||||
|---|---|---|---|---|---|---|
| Cut-off value | Fatalities n = 53 (12) | Survivors n = 377 (88) | OR 95% (CI) | p-value | HR (95%CI) | p-value |
| CRP >103 mg/L at day 4 | 33 (66) | 158 (43) | 2.6 (1.4–4.8) | 0.004 | 3.5 (1.2–10.3) | 0.024 |
| CRP >66 mg/L at day 7 | 27 (66) | 155 (43) | 2.6 (1.3–5.1) | 0.005 | - | - |
| CRP >61 mg/L at day 14 | 21 (84) | 74 (21) | 19.8 (6.6–59.4) | <0.0001 | 3.6 (1.1–10.3) | 0.039 |
| Fall of CRP <50% in 14 days | 13 (52) | 56 (16) | 5.7 (2.5–13.1) | <0.0001 | 2.0 (0.8–5.4) | 0.148 |
| Fall of CRP <50% between 7 to 14 days | 20 (87) | 151 (44) | 8.5 (2.5–29.2) | <0.0001 | - | - |
| WBC <4.5 or >10.3 x109/L at day 4 | 32 (63) | 166 (45) | 2.0 (1.1–3.7) | 0.024 | - | - |
| WBC <4.5 or >9.8 x109/L at day 7 | 34 (81) | 153 (42) | 5.8 (2.6–12.8) | <0.0001 | - | - |
| WBC >8.6 x109/L at day 14 | 17 (65) | 80 (23) | 6.5 (2.8–15.0) | <0.0001 | 8.2 (2.9–23.1) | <0.0001 |
| Age >60 years | 43 (80) | 174 (46) | 5.0 (2.4–10.3) | <0.0001 | 3.6 (1.1–11.5) | 0.029 |
| Malignancy | 13 (25) | 50 (13) | 2.1 (1.0–4.3) | 0.038 | 0.3 (0.1–1.2) | 0.087 |
| Ultimately or rapidly fatal diseaseb | 31 (59) | 88 (23) | 4.6 (2.5–8.4) | <0.0001 | 6.5 (2.4–17.6) | <0.0001 |
| Pneumonia | 34 (64) | 118 (31) | 3.9 (2.2–7.2) | <0.0001 | 8.1 (2.5–25.8) | <0.0001 |