Table 3. Factors associated with a deep infection focus in 430 patients with Staphylococcus aureus bacteremia.
OR = odds ratio for presence of deep infection, 95% CI = 95% confidence interval. All values are given as number of patients (%).
| Univariate analysis | Multivariate analysisa | |||||
|---|---|---|---|---|---|---|
| Deep infection n = 351 (82) | No deep infection n = 79 (18) | OR (95% CI) | p-value | OR (95%CI) | p-value | |
| Male sex | 224 (84) | 44 (56) | 1.4 (0.86–2.3) | 0.199 | - | - |
| Hospital-acquired | 178 (51) | 54 (68) | 0.48 (0.3–0.80) | 0.006 | - | - |
| Foreign bodyb | 82 (23) | 30 (38) | 0.50 (0.3–0.8) | 0.010 | - | - |
| IDUc | 43 (12) | 1 (1) | 11 (1.5–80.3) | 0.002 | 11.9 (1.5–93.2) | 0.018 |
| Chronic renal failured | 42 (12) | 18 (23) | 0.5 (0.2–0.9) | 0.064 | 0.47 (0.2–1.0) | 0.064 |
| Malignancy | 49 (78) | 14 (22) | 0.8 (0.4–1.4) | 0.383 | - | - |
| CRP >108 mg/L at day 1 | 264 (76) | 31 (39) | 4.9 (2.9–8.2) | <0.0001 | 2.6 (1.3–4.9) | 0.005 |
| CRP >72 mg/L at day 4 | 229 (68) | 30 (39) | 3.4 (2.0–5.6) | <0.0001 | - | - |
| CRP >44 mg/L at day 7 | 223 (67) | 20 (27) | 5.7 (3.2–10) | <0.0001 | 2.0 (1.0–4.3) | 0.063 |
| CRP >22 mg/L at day 14 | 177 (57) | 16 (23) | 4.4 (2.4–8.1) | <0.0001 | 3.9 (1.6–9.5) | 0.003 |
| Fall of CRP <50% in 14 days | 53 (17) | 16 (23) | 0.7 (0.4–1.3) | 0.301 | - | - |
| Fall of CRP <50% during the second week | 136 (46) | 35 (52) | 0.8 (0.5–1.3) | 0.420 | 0.5 (0.2–1.0) | 0.064 |
| WBC >8.0 x109/L at day 4 | 215 (63) | 34 (44) | 2.2 (1.4–3.7) | 0.002 | - | - |
| WBC >8.5 x109/L at day 7 | 189 (57) | 27 (37) | 2.4 (1.4–4.0) | 0.001 | - | - |
| WBC >7.25 x109/L at day 14 | 139 (45) | 19 (28) | 2.1 (1.2–3.8) | 0.010 | - | - |
Deep infection occurred at any time within the 30-day follow-up.
aBinary logistic regression analysis results
bForeign body implanted within a year
cIntravenous drug abuse during the 6 months preceding the positive blood culture.
dChronically elevated serum creatinine (≥180 μmol/l).