Skip to main content
. Author manuscript; available in PMC: 2016 May 16.
Published in final edited form as: Dev Biol. 2007 Jan 25;304(2):786–799. doi: 10.1016/j.ydbio.2007.01.027

Figure 2.

Figure 2

Effects of transgenic overexpression of Ptf1a-VP16 and Ptf1a on liver, stomach and duodenum. (A-C) Liver differentiation marker, transthyretin expression in stage 46/47 whole guts. (A) Control showing normal domain of TTR expression. Notice the size of the liver. (B) In Ptf1a transgenics transthyretin expression is normal. (C) Ptf1a-VP16 transgenic whole gut. Only a small domain of transthyretin expression is evident, located adjacent to the ectopic pancreas. (D-F) Expression of the stomach differentiation marker frp5 in stage 46/47 whole guts. (D) Frp5 expression in control whole guts extends from the duodenum through the stomach region (st+d), (E) Ptf1a transgenic whole gut. Almost no frp5 expression is detected. A small region at the posterior end of the pancreas and ectopic pancreas does express frp5 and may be marking a small remnant of the duodenum (“d”). (F) Ptf1a-VP16 transgenic whole gut-frp5 expression is normal.