Table 6. Pattern of 16S-23S IGS regions in parental strains and isogenic linezolid (LZD)-resistant mutants.
Strain | Type of 16S-23S IGS | ||||
---|---|---|---|---|---|
rrn1 | rrn2 | rrn3 | rrn4 | rrn5 | |
M2 | rrnH | rrnJ | rrnC | rrnE | rrnE |
M2/32/10a | rrnH | rrnJ | rrnC | rrnE | rrnE |
M2/128/15a | rrnH | rrnJ | rrnC | rrnE | rrnE |
M3 | rrnH | rrnJ | rrnC | rrnE | rrnE |
M3/64/29a | rrnH | rrnJ | rrnC | rrnE | rrnE |
M3/128/32a | rrnH | rrnJ | rrnC | rrnE | rrnE |
N315 | rrnC | rrnJ | rrnC | rrnE | rrnE |
Mu50 | rrnH | rrnJ | rrnC | rrnE | rrnE |
NCTC 8325 | rrnH | rrnH | rrnC | A48073 | rrnF |
MRSA252 | rrnY | rrnF | rrnC | rrnH | rrnZ |
a: wild type/LZD MIC/passage number (acquiring strains in step wise test) described by Tsuru T et al (ref 27).