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. 2016 Apr 22;1:16005. doi: 10.1038/sigtrans.2016.5

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Copyright © 2016 West China Hospital, Sichuan University

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Neovascularization and retinal degeneration in the PDR murine model. Hematoxylin and eosin (H&E)-stained pupil optic nerve sections from eight Chx10-cre; Vhl^flox/flox mice. At 1 month of age, the mice displayed signs of iris neovascularization (arrow) and protein extravasation in the anterior chamber (arrowhead), a sign of vascular leakage (a). There was optic disc neovascularization (arrow) and fibrosis in the vitreous (b), retinal photoreceptor degeneration (arrow) and vitreoretinal membranes (arrowhead) (c). Tractional vitreoretinal membranes (arrowhead) and vitreous neovascularization (arrow) were observed (d). N=12 eyes. All mice displayed neovascular and retinal degenerative phenotypes.