Fig. 2.

ANG II type 1 receptor (AT₁R) expression by immunohistochemistry in TSC patient renal angiomyolipomas. A: spindle and adipocyte-like cells of renal angiomyolipoma tissue from a patient with TSC displaying strong AT₁R positivity (×200 magnification). B: AT₁R-positive adipocyte-like cells (×600 magnification). C: AT₁R-positive epithelioid cells (×400 magnification). D: AT₁R-positive spindle cells (×400 magnification). E: mature fat, a capillary, and a vein from adjacent renal tissue were negative for AT₁Rs (×400 magnification). F: spindle cells surrounding a vessel displayed comparatively stronger AT₁R-positive signals (×400 magnification). Four separate TSC-associated angiomyolipomas were analyzed.