Table 2. Summary of cytokine results for biomarkers.
The median and interquartile range is reported for all biomarkers tested.
| Chagas Cardiomyopathy | Cardiomyopathy Chagas Ab+ | Non- Cardiomyopathy Chagas Ab+ | Seronegative | |
|---|---|---|---|---|
|
T. cruzi Parasitemia |
1.8 (0.16,5) | 0.31 (0,2.3) | 0.06 (0,1.8) | 0 (0,0) |
| Clinical Cardiac Measurements | ||||
| EF | 30 (20,40) | 58 (48,65) | 63 (60,65) | 62 (60,65) |
| ECG QTCCalculation |
457 (438,502) | 447 (423,462) | 424 (408,439) | 427 (411,442) |
| ECG QRSDuration |
140 (110,158) | 134 (112,144) | 88 (82,92) | 88 (82,95) |
| Cardiac Biomarkers | ||||
| Troponin | 0.012 (0.012,0.021) | 0.022 (0.013,0.04) | 0.012 (0.012,0.012) | 0.012 (0.012,0.012) |
| Myoglobin | 44 (35,55) | 40 (32,50) | 37 (30,46) | 37 (30,47) |
| NTproBNP | 747 (358,2224) | 76 (40,187) | 44 (26,72) | 39 (24,66) |
| CK-MB | 0.85(0.5407,1.269) | 1.06(0.6437,1.791) | 0.79(0.4853,1.297) | 0.68(0.417,1.17) |
| Adiponectin | 647800(647800,647800) | 647800(10050,647800) | 647800(8815,647800) | 647800(8536,647800) |
| MMP-9 | 174 (130,212) | 163 (118,225) | 158 (120,239) | 178 (127,243) |
| MPO | 35 (26,48) | 43 (26,79) | 40 (28,69) | 41 (28,96) |
| PAI-1 | 78 (54,106) | 83 (54,131) | 101 (65,132) | 106 (70,154) |
| Soluble Cell Adhesion Molecules | ||||
| sEselectin | 59 (46,71) | 64 (49,77) | 61 (43,77) | 58 (42,76) |
| ICAM | 339 (281,479) | 339 (270,406) | 338 (289,438) | 333 (270,400) |
| VCAM | 2229 (1922,2503) | 2185 (1806,2559) | 2042 (1680,2466) | 1963 (1657,2364) |
| Soluble Inflammatory Mediators | ||||
| CRP | 8387 (2971,14570) | 6055 (2314,13210) | 7362 (2411,14770) | 8095 (3055,15330) |
| SAA | 12390 (6428,27830) | 9487 (4648,18390) | 9301 (4785,19970) | 9407 (5114,18220) |
| SAP | 44670 (33060,58630) | 60660 (38990,87730) | 63780 (43540,88290) | 60770 (45370,88870) |
| IFNg | 0.21 (0.015,0.95) | 0.015 (0.015,0.67) | 0.015 (0.015,0.59) | 0.015 (0.015,0.55) |
| IL-10 | 4.3 (1.6,8) | 2.3 (0.12,4.7) | 1.5 (0.008,3.8) | 1.5 (0.008,4.3) |
| IL-1b | 0.024 (0.024,0.7) | 0.024 (0.024,0.069) | 0.024 (0.024,0.024) | 0.024 (0.024,0.024) |
| IL-6 | 1.6 (0.64,3.1) | 0.77 (0.091,1.7) | 0.57 (0.09,1.5) | 0.71 (0.09,1.7) |
| IL-8 | 2.2 (1.4,3.2) | 1.9 (1.2,3.4) | 1.8 (0.99,3.1) | 2 (1.2,3.2) |
| MCP-1 | 111 (91,143) | 118 (78,154) | 116 (82,158) | 131 (96,174) |
| TNF-a | 3.6 (2.5,5.5) | 3.4 (1.8,4.7) | 3 (1.7,4.8) | 3 (1.8,4.4) |
| VEGF | 41 (24,53) | 32 (10,53) | 32 (14,47) | 32 (7.5,49) |