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. 2016 Apr 25;113(19):5263–5268. doi: 10.1073/pnas.1524291113

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Fig. 2. — eIF4E nuclear trafficking affects its mRNA export activity. Effects of importin 8 (Imp8) knockdown on target mRNA export (A) and protein levels (C) in eIF4E-overexpressing (FLAG eIF4E) cells. Short hairpin control (shCtrl) indicates RNAi control, and c/n indicates the cytoplasmic-to-nuclear ratio. The c/n of tested mRNAs is shown. Results for endogenous eIF4E (endo eIF4E) upon importin 8 knockdown are shown in Fig. S3 A and B. Effects of importin 8 overexpression in the presence of endogenous eIF4E at the mRNA export (B) and protein levels (D) relative to vector controls (FLAG vect). Total mRNAs levels are unchanged (Fig. S3D), and fractionation controls are shown in Fig. S3C. Data are the mean ± SD. **P < 0.01; ***P < 0.001. ns, not significant.