Fig. 6.

Blue light functions through an adrenergic pathway. Mice were administered either equivolume saline (0.9%, i.p.) or the β₃ agonist CL316,243 (1 mg/kg, i.p.), and exposed to red, blue, or ambient light for 24 h. Mice were then subjected to unilateral kidney I/R (nine total mice per group for all four experiments combined). (A) Serum was analyzed for cystatin C concentration (ng/mL). Bar, median. (B) Kidney tissue was analyzed for MPO concentration (ng/mg tissue protein). Bar, median. (C) Mice were administered either equivolume saline (0.9%, i.p.) or the β₃ antagonist SR 59230A (5 mg/kg, i.p.) and then subjected to unilateral kidney I/R (six total mice per group for two experiments combined). Serum was analyzed for cystatin C concentration (ng/mL). Bar, median. Statistical comparisons were made by nonparametric Mann–Whitney test.