. 2016 Apr 26;113(19):5388–5393. doi: 10.1073/pnas.1522987113

Table 5.

16d in vitro absorption, distribution, metabolism, and excretion (ADME) studies

Papp^*	Membrane retention^†	LogS^‡	HLM stability^§
2.86·10⁻⁶	19.1	−7.05	99

HLM, human liver microsome; Papp, apparent permeability.

Papp reported in centimeters·seconds⁻¹.

^{^†}

Membrane retention expressed as percentage.

^{^‡}

Aqueous solubility.

^{^§}

HLM metabolic stability expressed as percentage of unmodified parent drug.