Table 6.

Pharmacokinetic parameters of 16d after i.v. administration at a dose of 10 mg·kg⁻¹

Pharmacokinetic parameters	16d*
Dose (mg/kg)	10.00
MRT (h)	3.98 ± 0.38
AUC0–∞ (μg × h/mL)	39.95 ± 13.50
AUC0–24 (μg × h/mL)	39.77 ± 13.51
CL (mL/min)	1.29 ± 0.54
t1/2β (h)	3.19 ± 0.24

AUC, area under the plasma concentration–time curve; CL, plasma clearance; MRT, mean residence time; t_1/2β, plasma half-life.

^*All data are expressed as means ± SDs (n = 3).