Distribution of the MIB and MIP homologs in Mollicutes. The occurrence of a gene homolog of MIB, MIP, protein M, or a gene annotated DUF31 is indicated by rectangles colored in red, green, dark blue, and light gray, respectively. Adjoining rectangles denote genes located on the same loci. Vertical alignment of the symbols does not infer synteny. The host specificity of the Mollicutes species is indicated as follows: black, animal host; cyan, human host; green, plant host. The phylogenetic tree was inferred using the maximum-likelihood method from the concatenated multiple alignments of 79 proteins encoded by genes present at one copy in each genome. Main phylogenetic groups are indicated: S, spiroplasma; H, hominis; P, pneumoniae; and AAP, acholeplasma/phytoplasma.