The most common glycolytic routes in prokaryotes. EMP, often simply referred to as glycolysis, is shown in red with key enzyme PFK; the OPP pathway is shown in blue with enzyme Zwf; and the ED pathway is shown in green with key enzyme KDPG aldolase (Eda). Reactions that are shared by all pathways are shown in black. The EMP and OPP pathways are known to operate in cyanobacteria and plants. We show that in addition, the ED pathway operates in cyanobacteria and plants. Eda, KDPG aldolase; Edd, phosphogluconate dehydratase; Eno, enolase; Fba, fructose bisphosphate aldolase; Gdh, glucose dehydrogenase; Gk, gluconate kinase; Gnd, 6-phosphogluconate dehydrogenase; Pfk, 6-phosphofructokinase; Pgi, phosphoglucose isomerase; Pgk, phosphoglycerate kinase; Rpe, ribulose-5-phosphate epimerase; Rpi, ribulose-5-phosphate isomerase; Tal, transaldolase; Tim, triosephosphate isomerase; Tkt, transketolase; Zwf, glucose-6-phosphate dehydrogenase.