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Effect of partial inactivation of δ-COP on Aβ level in 2xTg AD mice. (A) Measurements of Aβ40 and Aβ42 in the hippocampus of age-matched 2xTg AD mice (AD/δ-COP WT vs. AD/δ-COP mut mice) (n = 6–11 per genotype; one outlier has been excluded among the 9-mo-old mice). (B) Analysis of APP and actin levels by Western blotting. (*P < 0.05, **P < 0.01, ****P < 0.0001, two- or one-tailed Student’s t test or Mann–Whitney test. The results are shown as means ± SEM.)
