Fig. 5.

Effect of partial inactivation of δ-COP on memory in 2xTg AD mice. (A and B) Effect of δ-COP on novel object recognition in 9-mo-old male mice in (A) a WT or (B) an AD background. Measurement of time spent with a novel versus familiar object. (C) Measurement of the number of visits to the novel versus familiar object (n = 5–14 per genotype). (*P < 0.05, one-tailed Student’s t test or Mann–Whitney test; n.s., not significant. The results are shown as means ± SEM.)