Fig. S4.

Serum glucose levels of C57BL/6J mice used in this study. Hyperglycemia was induced by i.p. administration of STZ, and only mice with serum glucose >350 mg/dL were considered diabetic. The results were evaluated using one-way ANOVA followed by Bonferroni post hoc analysis. P < 0.001 denotes statistical differences between the STZ-treated and wild-type control groups. Studies were performed on mice at 6 wk and 20 wk of sustained hyperglycemia and were compared with results in age-matched control mice.