Fig. S7.
Pharmacokinetics of chimeric activator 10F7-EPOR150A. (A) huGYPA transgenic or nontransgenic mice were given a single 25-μg dose of 10F7-EPOR150A i.v. (B and C) Blood was collected in a 72-h time course to measure drug in plasma by ELISA (B) or RBC-bound drug by flow cytometry (C). Measurements are relative to the amount of drug detected at T = 0 (100%). Graphs display mean ± SEM (n = 2) and the terminal plasma and RBC-bound half-lives of 10F7-EPOR150A in huGYPA transgenic and nontransgenic mice.