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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Curr Opin Cardiol. 2016 May;31(3):235–241. doi: 10.1097/HCO.0000000000000274

FIGURE 2.

FIGURE 2

Reciprocal ovarian transplants between young and old mothers localize the basis of the maternal-age-associated risk to the mother. The incidence of ventricular septal defects for the offspring of old mothers with young ovaries is significantly greater than that of young mothers with old ovaries. The observed incidence in the offspring of recipient mothers matches that expected for a maternal but not an oocyte basis of the age effect. The observed and expected incidences were compared in a chi-squared goodness-of-fit test. The number of recipient mothers and the number of pups in each age group are shown. Reproduced with permission from [19▪▪]. VSD, ventricular septal defect.