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(A) Schematic representation of NT/NTR1 signaling in a colitic flare involving the transcription factor HIF-1α and miR-210. (+) indicate stimulation while (−) indicate inhibition of downstream targets. Solid arrows indicate intracellular effects while doted arrows indicate effects intercellular communication. (B) Schematic representation of the anti-inflammatory role of in vivo silencing of miR-210.
