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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: J Immunol. 2016 Apr 6;196(10):4196–4203. doi: 10.4049/jimmunol.1600081

Figure 1. Prevalent CA-MRSA strains are more resistant to innate clearance from the lower airways.

Figure 1

(A) Lung bacterial burdens at 5 and 24 h after infection of C57BL/6 mice (n=5) with 107 CFU of MRSA LAC-JE2 (LAC), MW2 or BAA-1695. (B) Relative numbers of bacteria remaining in the lungs (n=4) 5 h after S. aureus infection. The CFU mean±s.d. are represented as percentages of the bacterial titer in the inoculum. (C) TNF-α levels, (D) representative flow cytometry plots and (E) frequencies (mean±s.d.) of alveolar macrophages (CD11c+) and neutrophils (CD11c−Ly6G+) in the airways (n=5) at 5 and 24 h after infection of C57BL/6 mice with 107 CFU of MRSA LAC-JE2, MW2 or BAA-1695. *P< 0.05, ***P< 0.001, Tukey's multiple comparisons test. Data shown are representative of two independent experiments.