Table 5.
Outcomes of patients admitted to the intensive care unit within 1 year of hematopoietic stem cell transplantation. ARDS = Acute Respiratory Distress Syndrome. HSCT = Hematopoietic Stem Cell Transplant. SOFA = Sequential Organ Failure Assessment score. APACHE = Acute Physiology and Chronic Health Evaluation.
| Patients admitted to the ICU within 1 year following HSCT | |||
|---|---|---|---|
| ARDS | No ARDS | p | |
| Total number | 133 | 407 | |
| Age | 52.5 ± 12.0 | 56.6 ± 13.1 | 0.001 |
| Male | 73 (56.2%) | 237 (58.2%) | 0.6 |
| Time to ARDS following HSCT (days) | 28.5 (11.9 – 133) | n/a | |
| ARDS Severity | |||
| Mild | 9 (6.8%) | n/a | |
| Moderate | 30 (22.6%) | n/a | n/a |
| Severe | 94 (70.7%) | n/a | |
| ARDS Risk Factors | |||
| Aspiration | 13 (9.8%) | 4 (1%) | < 0.001 |
| Emergency / High Risk Surgery | 3 (2.3%) | 5 (1.2%) | 0.41 |
| Pancreatitis | 0 (0%) | 0 (0%) | n/a |
| Pneumonia | 105 (78.9%) | 87 (21.4%) | < 0.001 |
| Sepsis | 102 (76.7%) | 272 (66.8%) | 0.004 |
| Shock | 89 (66.9%) | 214 (52.6%) | 0.03 |
| Trauma | 1 (0.8%) | 0 (0%) | n/a |
| Outcomes | |||
| ICU mortality | 51 (38.3%) | 19 (4.7%) | < 0.001 |
| Hospital mortality | 76 (57.1%) | 40 (9.8%) | < 0.001 |
| 28-day mortality | 62 (46.6%) | 40 (9.8%) | < 0.001 |
| ICU length of stay | 7.9 (2.2 – 13.2) | 1.3 (0.8 – 2.9) | < 0.001 |
| ICU length of stay (survivors) | 7.5 (3.0 – 11.5) | 1.2 (0.8 – 2.8) | < 0.001 |
| Hospital length of stay | 25.3 (11.0 – 44.1) | 9.0 (4.3 – 17.3) | < 0.001 |
| Hospital length of stay (survivors) | 23.6 (13.1 – 38.6) | 8.8 (4.2 – 15.8) | < 0.001 |
| APACHE-III score | 97.8 ± 28.9 | 78.1 ± 24.6 | < 0.001 |
| SOFA score | 10.7 ± 4.0 | 6.0 ± 3.7 | < 0.001 |