Table 2. Genome rearrangements resulting in fusion transcripts identified in three cell lines.
Sample | Gene fusion | Rearrangement type |
---|---|---|
IOR/OS15 | PMP22-ELOVL5 | Translocation |
IOR/OS15 | GCC2-CCDC73 | Translocation |
IOR/OS15 | RAI1-CLIC5 | Translocation |
IOR/OS15 | TP53-PPRAD | Translocation |
IOR/OS15 | MRPL39-MAML3 | Translocation and deletion |
IOR/OS15 | PLXNA2-RUNX1 | Translocation |
IOR/OS15 | SCO1-CLIC5 | Translocation |
IOR/OS15 | EIF2S1-RBM25 | Deletion |
IOR/OS15 | BAZ1A-NUMB | Deletion |
IOR/OS15 | CDC5L-BTBD9 | Inversion |
IOR/OS15 | MRPL39-NRIP1 | Inversion |
MG-63 | DNER-ELL2 | Translocation |
MG-63 | CLIP4-EPHB4 | Translocation |
MG-63 | TP53-VAV1* | Translocation |
MG-63 | TP53-EMR1* | Translocation |
MG-63 | MROH1-PARP10 | Inversion |
MG-63 | BNC2-MTAP | Inversion |
ZK-58 | CREBBP-TFAP4 | Deletion |
ZK-58 | GDPD5-MAP6 | Deletion |
One genomic translocation (TP53-VAV1) causing two different fusion transcripts involving the gene at the breakpoint (VAV1) and the gene next to it (EMR1).