Table 2. Univariate and multivariate Cox Proportional Hazards Regression Analyses of factors associated with Mortality.
| Variables | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| B | HR | 95%CI | P-value | B | HR | 95%CI | P-value | |
| NLR | 0.039 | 1.040 | 1.015-1.065 | 0.001 | 0.031 | 1.031 | 1.002-1.060 | 0.033 |
| Demographic parameters | ||||||||
| Age (years) | 0.008 | 1.008 | 0.993-1.023 | 0.284 | ||||
| Gender | −0.036 | 0.965 | 0.602-1.547 | 0.881 | ||||
| BMI | 0.005 | 1.005 | 0.952-1.06 | 0.865 | ||||
| Clinical parameters | ||||||||
| Ascites | 0.000 | 1.000 | 1.000-1.000 | 0.007 | ||||
| Liver cirrhosis | 0.198 | 1.219 | 0.852-1.746 | 0.279 | ||||
| Laboratory parameters | ||||||||
| Total bilirubin (μmol/L) | 0.005 | 1.005 | 1.000-1.010 | 0.057 | ||||
| Direct bilirubin (μmol/L) | 0.006 | 1.006 | 0.999-1.012 | 0.101 | ||||
| Albumin (g/L) | −0.061 | 0.941 | 0.917-0.966 | <0.001 | ||||
| ALT (IU/L) | 0.002 | 1.002 | 1.000-1.003 | 0.041 | ||||
| AST (IU/L) | 0.001 | 1.001 | 1.000-1.002 | 0.005 | ||||
| Alkaline phosphatase (IU/L) | 0.002 | 1.002 | 1.001-1.003 | 0.006 | ||||
| γ-GT (IU/L) | 0.001 | 1.001 | 1.000-1.002 | 0.047 | ||||
| Blood glucose (mmol/L) | 0.046 | 1.047 | 1.004-1.092 | 0.032 | ||||
| Creatinine (μmol/L) | −0.004 | 0.996 | 0.987-1.005 | 0.408 | ||||
| Uric acid (μmol/L) | 0.000 | 1.000 | 0.998-1.002 | 0.978 | ||||
| Serum sodium (mmol/L) | 0.003 | 1.003 | 0.998-1.008 | 0.276 | ||||
| PT (s) | 0.152 | 1.164 | 1.039-1.305 | 0.009 | ||||
| PTA (%) | −0.015 | 0.985 | 0.973-0.997 | 0.013 | ||||
| INR | 0.008 | 1.008 | 0.988-1.028 | 0.433 | ||||
| White blood cell (109/L) | 0.025 | 1.025 | 1.009-1.041 | 0.002 | ||||
| Platelet (109/L) | 0.003 | 1.003 | 1.000-1.005 | 0.038 | ||||
| AFP (ng/mL) | 0.000 | 1.000 | 1.000-1.000 | 0.007 | ||||
| Tumor Characteristics | ||||||||
| Number of nodules | 0.423 | 1.526 | 1.225-1.901 | <0.001 | 0.518 | 1.679 | 1.285-2.194 | <0.001 |
| Greatest tumor diameter (mm) | 0.010 | 1.010 | 1.005-1.014 | <0.001 | ||||
| Portal vein thrombosis | 1.778 | 5.919 | 2.835-12.358 | <0.001 | 1.465 | 4.329 | 1.968-9.521 | <0.001 |
| Microvascular invasion | 0.897 | 2.453 | 1.770-3.399 | <0.001 | 0.927 | 2.527 | 1.726-3.700 | <0.001 |
| CLIP score | 0.445 | 1.560 | 1.342-1.813 | <0.001 | ||||
| CTP score | 0.691 | 1.996 | 1.418-2.810 | <0.001 | 0.516 | 1.675 | 1.153-2.433 | 0.007 |
NOTE. B, coefficient; HR, hazard ratio; CI, confidence interval; NLR, neutrophil-lymphocyte ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; γ-GT, γ-glutamyl transferase; PT, prothrombin time; PTA, prothrombin time activity; AFP, alpha-fetoprotein; INR, international normalized ratio; CLIP, Cancer of The Liver Italian Program; CTP, Child-Turcotte-Pugh.