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. 2015 Dec 26;7(5):5576–5597. doi: 10.18632/oncotarget.6762

Figure 4. Dimer formation pattern in MCF-7 cells (A) and SKBR3 cells.

Figure 4

The data analysis was done using Duolink Image Tool Software and representative images of each context are shown. White arrowheads point to positive signal (red dots) of dimer formation using the Duolink in situ PLA (scale bar, 20 μm). EGFR = HER-1; PLA, proximity ligation assay. Dimer formation pattern in MCF-7 cells (B) after the addition of heregulin (HRG) and trastuzumab plus pertuzumab. The data analysis was done using Duolink Image Tool Software and representative images of each context are shown. White arrowheads point to positive signal (red dots) of dimer formation using the Duolink in situ PLA (scale bar, 20 μm). EGFR = HER-1; PLA, proximity ligation assay.