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. 2015 Dec 31;7(5):5852–5864. doi: 10.18632/oncotarget.6809

Figure 2. The distribution of validated integration breakpoints.

Figure 2

(A) 117 validated integration breakpoints, identified in 25 HPV-positive cases including cell lines of SiHa and HeLa, are shown according to position in HPV genome. 99 validated HPV16 integration breakpoints identified in 19 primary cervical cancer samples are shown in black, 2 HPV16 integration breakpoints in SiHa cell line in red, 3 HPV18 integration breakpoints in 3 primary cervical cancer samples in blue, 4 HPV18 integration breakpoints in HeLa cell line in green, and 9 HPV58 integration breakpoints in 1 primary cervical cancer sample in purple. (B) The frequencies of 99 validated integration sites in 19 HPV16-positive primary cervical cancer samples are shown, ranging from 1 to 19 per sample. See also Table 1 and Supplementary Table S1.