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. 2016 Jan 5;7(5):5865–5876. doi: 10.18632/oncotarget.6823

Figure 2. Diabetes induces neuronal pathology in the PC along aging.

Figure 2

a., b., c. Number of NeuN-positive neurons presenting normal morphology a., number of Calbindin-D28k-positive interneurons b. and of their neurites c. in the PC of 3- and 13-month-old Wistar and GK rats. d. Representative photomicrographs demonstrating the morphology of NeuN-positive neurons. Arrows indicate neurons with abnormal NeuN immunoreactivity. e. Representative photomicrographs demonstrating morphology of Calbindin-D28k-positive cells with visibly reduced neuronal branching and soma size in 13-month-old GK rats. Scale bars 50μm. Bars indicate means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (n = 6-7).