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. 2016 Jan 5;7(5):5865–5876. doi: 10.18632/oncotarget.6823

Figure 5. Ex-4 counteracts neuronal pathology in the PC of GK rats.

Figure 5

a., b. Number of total and normal/healthy NeuN-positive neurons (a) and representative photomicrographs demonstrating their morphology (b) in the PC of 9-months-old GK vehicle- (n = 8) and Ex-4-treated (n = 10) GK rats. Arrows indicate neurons with abnormal NeuN immunoreactivity. c., d., e. Number of Calbindin-D28k-positive interneurons (c) and number of their neurites (d) in control and Ex-4-treated GK rats, and representative photomicrographs showing the Ex-4 effect (e). Scale bars 50 μm. Bars indicate means ± SEM. *P < 0.05, ***P < 0.001, ****P < 0.0001.