Table 1. The cytotoxic effect of doxorubicin (DOX), DOX-loaded Tea nanoparticles (DOX-TNP) and TNP on CCD-18Co, SW620 and SW620/Ad300 cell lines.
| Treatment | CCD-18Co | SW620 | SW620/Ad300 | |||
|---|---|---|---|---|---|---|
| IC50 ± SDa (μM) | CRb | IC50 ± SD (μM) | CR | IC50 ± SD (μM) | CR | |
| DOX | 0.190 ± 0.015 | [21.1] | 0.077 ± 0.006 | [8.6] | 4.430 ± 0.190 | [492.2] |
| DOX-TNP | 0.043 ± 0.010 | [4.8] | 0.009 ± 0.001 | [1.0] | 0.852 ± 0.055 | [94.7] |
| TNP | > 300 μM | > 300 μM | > 300 μM | |||
a
IC50: concentration that inhibited cell survival by 50% (means ± SD).
b
CR: cytotoxicity ratio was the value of IC50 value for DOX or DOX-loaded TNP on CCD-18Co, SW620 or SW620/Ad300 cells was divided by IC50 value for DOX-loaded TNP on SW620 cells.
Values in table are representative of at least three independent experiments performed in triplicate.