Figure 4.

A. Expression of 17 genes (log10 scale on the y axis) included in the metastasis-associated gene signature was analyzed in patients with pancreatic cancer with positive or negative serum CA125 expression. The cut-off value of serum CA125 for predicting pancreatic cancer metastasis was identified as 18.4 U/mL. The lines across the dot plots indicate the median values. B. Two categories of patients classified by positive/negative baseline serum CA125 levels were largely consistent with two clusters based on hierarchical clustering of the metastasis-associated gene signature.