Table 3. Univariate and multivariate cox regression analyses of serum tumor markers for OS and RFS in shanghai cancer center.
| Features | OS | RFS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analyses | Multivariate Analyses | Univariate analyses | Multivariate Analyses | |||||||||
| HR | 95 % | P | HR | 95 % | P | HR | 95 % | P | HR | 95 % | P | |
| Preoperative CA19-9 (≥ 37 vs.< 37 U/mL) | 1.997 | [1.271, 3.139] | 0.003 | 1.811 | [1.148-2.856] | 0.011 | 2.171 | [1.476, 3.194] | < 0.001 | 1.869 | [1.262, 2.768] | 0.002 |
| Preoperative CA125 (≥ 18.4 vs.< 18.4 U/mL) | 2.431 | [1.708, 3.460] | < 0.001 | 2.315 | [1.620-3.308] | < 0.001 | 2.841 | [2.086, 3.871] | < 0.001 | 2.454 | [1.778, 3.387] | < 0.001 |
| Preoperative CEA (≥ 5.2 vs.< 5.2 ng/mL) | 1.587 | [1.103, 2.285] | 0.013 | NS | 1.766 | [1.292, 2.412] | < 0.001 | 1.467 | [1.065, 2.022] | 0.019 | ||
| Preoperative CA242 (≥20 vs.< 20 U/mL) | 1.795 | [1.249, 2.580] | 0.002 | NS | 1.882 | [1.381, 2.566] | < 0.001 | NS | ||||
| Preoperative CA724 (≥6.9 vs.< 6.9 U/mL) | 0.988 | [0.619, 1.576] | 0.958 | NS | 1.271 | [0.866, 1.866] | 0.221 | NS | ||||
| Preoperative CA50 (≥25 vs.< 25 U/mL) | 1.530 | [1.060, 2.207] | 0.023 | NS | 1.382 | [1.018, 1.877] | 0.038 | NS | ||||
| Preoperative CA153 (≥25 vs.< 25 U/mL) | 1.114 | [0.668, 1.858] | 0.678 | NS | 1.202 | [0.775, 1.865] | 0.410 | NS | ||||
| Preoperative AFP (≥10 vs.< 10 ng/mL) | 0.609 | [0.248, 1.492] | 0.278 | NS | 0.555 | [0.260, 1.184] | 0.127 | NS | ||||
| Postoperative CA19-9 (non-decrease vs. decrease) | 2.551 | [1.756, 3.704] | < 0.001 | 2.008 | [1.352-2.982] | 0.001 | 2.568 | [1.844, 3.576] | < 0.001 | 2.374 | [1.677, 3.360] | < 0.001 |
| Postoperative CA125 (non-decrease vs. decrease) | 2.579 | [1.787, 3.720] | < 0.001 | 2.078 | [1.419-3.041] | < 0.001 | 1.914 | [1.411, 2.597] | < 0.001 | 1.600 | [1.166, 2.195] | 0.004 |
| Postoperative CEA (non-decrease vs. decrease) | 1.954 | [1.378, 2.770] | < 0.001 | 1.467 | [1.017-2.117] | 0.040 | 1.618 | [1.191, 2.199] | 0.002 | NS | ||
| Postoperative CA242 (non-decrease vs. decrease) | 1.685 | [1.183, 2.400] | 0.004 | NS | 1.403 | [1.029, 1.914] | 0.032 | NS | ||||
| Postoperative CA724 (non-decrease vs. decrease) | 1.431 | [1.010, 2.029] | 0.044 | NS | 1.392 | [1.030, 1.880] | 0.031 | NS | ||||
| Postoperative CA50 (non-decrease vs. decrease) | 1.822 | [1.272, 2.608] | 0.001 | NS | 1.594 | [1.165, 2.183] | 0.004 | NS | ||||
| Postoperative CA153 (non-decrease vs. decrease) | 1.562 | [1.106, 2.206] | 0.011 | NS | 1.384 | [1.027, 1.864] | 0.033 | NS | ||||
| Postoperative AFP (non-decrease vs. decrease) | 1.159 | [0.792, 1.698] | 0.448 | NS | 1.010 | [0.722, 1.415] | 0.952 | NS | ||||
Note: All eight serum markers were adopted in multivariate analyses with forward-stepwise features selection. NS: not significant